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Midway, UT 84049
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SpringTree Health

We've created the most complete multi-vitamins and supplements available using the highest quality ingredients so you can feel at ease knowing you and your family are taking the best vitamins for your health.


Better ingredients for a better life

Methylation Factors

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Methylation Factors

from 26.95

Methylation Factors from SpringTree Health provides 5-MTHF (active folate) and the active, bioavailable forms of vitamins B2 (Riboflavin), B3 (as Inositol Hexanicotinate), B6 (Pyridoxyl-5-Phosphate), and B12 (Methylcobalamin, Hydroxycobalamin, and Adenosylcobalamine) to support healthy methylation for cardiovascular, cognitive, and bone health.* These bioactive B-viamins, together with Trimethylglycine, NAC, Turmeric, Zinc, Milk Thistle Extract, and Potassium support methylation processes and normal homocysteine metabolism.

As much as 40% of the population has at least one mutation in several genes which code for the enzyme Methylenetetrahydrofolate reductase (MTHFR). SpringTree Health’s Methylation Factors has added ingredients many other methylation support supplements don’t have with the goal to improve the breakdown of the methyl products after they are used to reduce the risk of over-methylation.

SpringTree Health seeks to formulate and manufacture high-quality, highly-bioavailable, supplements. These statements have not been evaluated by the Food and Drug Administration (FDA). These products are not meant to diagnose, treat or cure any disease or medical condition. Caution is advised to start slow and increase slowly. Always consult your holistic physician prior to starting this, or any other supplement program.

*Caution is advised to start slow and increase slowly

Manufactured in the USA in a GMP-certified facility, and stored in a temperature controlled location for guaranteed quality and potency.

*Best taken with food

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Approximately 40% of the population have at least one mutation in several genes which code for the enzyme Methylenetetrahydrofolate reductase, which adds a methyl group (1 carbon and 3 hydrogen) to B-12 and folate so the cells can use them.  The mutations reduce the ability of the cells to do that, so the body ends up with a relative deficiency (though blood levels may be normal or high) of these important nutrients.   Mutations of these genes have been implicated in increasing the risk of heart disease, Alzheimer’s and dementia, neural tube defects, colon cancer, leukemia, breast cancer, prostate cancer, mood disorders and schizophrenia, autistic spectrum disorders, neuropathy and other nervous system disorders, chronic fatigue, fibromyalgia, irritable and inflammatory bowel syndrome, miscarriages, migraines, chemical sensitivities, elevated levels of toxins which increase other diseases, and more.

Methylation Factors is probably the least expensive high quality methylation supplement on the market.  It has added ingredients most other methylation supplements don’t have with the goal to improve the breakdown of the methyl products after they are used to reduce the risk of over-methylation.


Each capsule contains:

5-MTHF 1000 mcg—the activated form of folate

Methylcobalamine, Hydroxycobalamin and Adenosylocobalamine for a total of 1000 mcg

Pyridoxyl-5-Phosphate       25 mg—the activated, methylated form of B-6, often necessary in the cell’s utilization of B-12 and folate

Betaine Anhydrous (Trimethylglycine) 250 mg—a methyl donor

Riboflavin 25 mg—low levels of riboflavin may interfere with the metabolism of folate, particularly in individuals homozygous for the MTHFR C677T gene variant

Zinc 5 mg—many of the enzyme processes utilizing B-12 and folate are zinc dependent

Inositol Hexanicotinate (non-flush niacin) 25 mg—used in breaking down methyl products after they have been used; reduces the “over-methylation” effects

·N-acetyl-cysteine (NAC) 100 mg—the precursor of glutathione, more absorbable and less expensive than glutathione itself.  An MTHFR mutation may reduce the production of glutathione, the body’s most powerful anti-oxidant and detoxifier.  Increased glutathione also reduces the “over-methylation” effects by both means—reducing oxidation and detoxifying.

Turmeric  100 mg—many people with MTHFR mutations have high levels of inflammation which increase the risk of side effects from methylation products.  Tumeric has been shown to reduce inflammation and prevent increased pain.

Milk Thistle Extract 150 mg—supports the liver through the increased detoxification that comes with taking the methylated vitamins.

Potassium 50 mg—restoring  B-12 after long-term deficiency can cause potassium deficiency because as B-12 is restored, the body starts making more blood cells, and this process uses up potassium, increasing muscle pain and spasms.

Caution is advised to start slow and increase slowly.  If one capsule causes symptoms, start with just a quarter or half an opened capsule to get the body used to the methylation.  Some people need higher levels of niacin to break down the extra methyl products.  Work with an integrative health care practitioner that is knowledgeable in the MTHFR mutations.  With care the great majority of people with these mutations can improve in health and well-being and prevent future problems.